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Fall 2004/2005

Staphylococcus-like organisms on samples of wood collected from steam baths. (Image courtesy of CDC/ Janice Carr.)

Highlights of this Course

This course introduces students to the principles of infectious agents. With an empahasis on pathobiology, lecturers chosen for their expertise and speaking ability cover a wide range of topics from Streptococcus to Fastidious Bacteria. The course also includes a Wet-lab hands-on experience.

Course Description

The intent of this course is to introduce students to basic tactics used by microbial pathogens to establish infectious diseases. As such, students should understand that most of the principles detailed in the course will be encountered several times during the next year of studies, particularly in the Infectious Diseases unit. The topics covered in this course deal selectively with important pathogens because Medical Microbiology will not be the only exposure of the student to infectious agents. As examples, HIV is only covered in two lectures, but you will have other opportunities to review the basics of disease caused by this virus.

An understanding of the principles of infectious agents calls for some hands-on experience, so this course also includes a wet~lab that most students regard as fun and painless. Some of the things learned in the wet-lab will eventually be utilized by all of you in the clinic. Participation in the lab is required for successful completion of the course, and a detailed lab summary will be required of all students after the last lab session.

Microbiology is taught in conjunction with Pathophysiology of Infectious Diseases and Pharmacology, both of which courses contain essential subject matter in the field of Medical Microbiology that will not be found in this course.

Popular Content

    * Streptococcus Lecture Slides
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    * Students will begin to understand the strategies used by microbial pathogens to establish infectious disease in the host.
    * Students will demonstrate an understanding of the process of microbial and parasitic infection, including a laboratory experience designed to detect microbial growth and identification.
    * Students will enhance their skills in scientific communication and continued learning through the laboratory experience.


Notes on required readings.

You will have access to most of the lecture slides. You will receive lecture outlines and assigned readings in the textbook: Mechanisms of Microbial Diseases (3rd edition) by Schaechter, Medoff and Eisenstein, Williams and Wilkins Press.

Complete digestion of the assigned readings in this textbook is absolutely required for successful completion of the course, and everyone must have a copy. Some exam questions derive from the assigned readings without coverage during the lectures. You should note that the book is somewhat unusual, in that it is not exhaustive in its coverage of any topic; rather, it reads more like lecture notes, which is its intent. In addition, most of the lecturers have provided rough outlines of their lectures in this syllabus, but these outlines are just intended to give either a 'head-start' on recording lecture material and/or a 'most important' distillate of lecture material. Often, the provided outline reflects how the lecturer thinks about a topic, and should not be viewed as a replacement for the textbook.

Notes on recommended readings.

Although successful completion of this course will not require the student to study anything other than the textbook, lectures and lecture outlines, several books have been found to be useful. Two of these,

   1. Microbiology / Bernard D. Davis ... [et al.]. Philadelphia : Lippincott, c1990.
   2. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases / edited by Gerald L. Mandell, John E. Bennett, Raphael Dolin.Philadelphia : Churchill Livingstone, c2000.

are the sort of style of textbooks that you might be more familiar with. There should not be any real necessity to use these books except to resolve some specific confusing point in the textbook or lectures. Mims' Pathogenesis of Infectious Disease (Mims' pathogenesis of infectious disease. London ; San Diego : Academic Press, 1995) is a book that every student should skim at sometime in their careers, and now is as good a time as any. Another text is Mechanisms of Microbial Diseases (3rd edition) by Schaechter, Medoff and Eisenstein, Williams and Wilkins Press and . Remember, however, concentrating on the textbook rather than outside reading should be fine.

Grades and Exams

One multiple-choice quiz will be given, and the questions will draw from material in the first 6 lectures. The quiz will account for 5% of your final grade. Two multiple-choice exams will be given, a Mid-term and a Final, and each will account for 45% of your final grade. The remaining 5% of your final grade will come from the laboratory portion of the course. The Mid- term will cover everything in the lectures from the first lecture and up to and including the lecture on Opportunistic Infections. The Final will only cover material beginning with the lecture on Intestinal Helminths and extending to the last lecture (Viral Exanthams), so it is not comprehensive. Some exam questions will draw on what you learn in the laboratory. Some exam questions will draw partially or entirely on what you learn in the textbook assigned chapters. Finally, most questions will draw partially or entirely on material covered in the lectures and from lecture outlines.

Session   Type Title  
1 Lecture Microbiology Introductory  
2 Lecture Host Parasite Interactions  
3 Lecture Normal Flora  
4 Laboratory Lab #1  
5 Laboratory Lab #2  
6 Lecture Phagocytosis  
7 Laboratory Lab #3  
8 Lecture Damage to Host  
9 Lecture Streptococcus  
10 Lecture Staphylococci  
11 Laboratory Lab #4  
12 Lecture Neisseriae  
13 Examination Quiz  
14 Laboratory Lab #5  
15 Lecture Enteric Bacteria  
16 Laboratory Lab #6  
17 Lecture Fastidious Bacteria  
18 Lecture Anaerobic Bacteria  
19 Lecture Chlamydia/Rickettsiae  
20 Lecture Spirochettes  
21 Lecture Opportunistic Infections  
22 Lecture Review for Midterm  
23 Examination Midterm Exam  
24 Lecture Intestinal Helminths  
25 Lecture Malaria  
26 Lecture HIV Pathogenesis  
27 Lecture AIDS  
28 Lecture Toxoplasma/Leishmaniasis  
29 Lecture Fungi  
30 Lecture Hepatitis  
31 Lecture Enteroviruses  
32 Lecture Respiratory Viruses  
33 Lecture Herpes I  
34 Lecture Herpes II  
35 Lecture Intestinal Protozoa  
36 Lecture Viral Exanthams  
37 Lecture Review for Final Exam  
38 Examination Final Exam   Tell A Friend