 
Abstract/Syllabus:

Chemicals in the Environment: Toxicology and Public Health (BE.104J)
Spring 2005
Oil floating on the River Irwell near the Manchester UK city center. (Photo courtesy of Matt Cox.)
Course Highlights
This course features lecture notes and a full set of assignments.
Course Description
This course addresses the challenges of defining a relationship between exposure to environmental chemicals and human disease. Course topics include epidemiological approaches to understanding disease causation; biostatistical methods; evaluation of human exposure to chemicals, and their internal distribution, metabolism, reactions with cellular components, and biological effects; and qualitative and quantitative health risk assessment methods used in the U.S. as bases for regulatory decisionmaking. Throughout the term, students consider case studies of local and national interest.
Syllabus
Required Texts
Salsburg, D. The Lady Tasting Tea: How Statistics Revolutionized Science in the Twentieth Century. New York, NY: W. H. Freeman and Company, 2001. ISBN: 9780716741060.
Gordis, L. Epidemiology. 3rd ed. Philadelphia, PA: W.B. Saunders, 2004. ISBN: 9780721603261.
Schork, M. A., and R. D. Remington. Statistics with Applications to the Biological and Health Sciences. 3rd ed. Upper Saddle River, NJ: PrenticeHall, 2000. ISBN: 9780130223272.
Grading Policy
Percentage contributions to the final grade are as follows:
Grading Table
Activities 
Percentages 
Quizzes (Two, 25% each) 
50% 
Homework Assignments (10page Book Critique, 10%; 5 Problem Sets, 15%) 
25% 
Team Project (Team Project Paper, 15%; Team Project Presentation, 10%) 
25% 
Recitations
There will be optional weekly recitation sessions offered throughout the term. However, students are strongly encouraged to attend. In addition to answering questions relating to the lecture material, homework assignments, and projects, the TA will provide background help with concepts in several areas, including epidemiology and biostatistics for the first half and elements of chemistry and biochemistry and risk analyses for the second.
Reading Assignment for "The Lady Tasting Tea"
During the first half of the term, students are required to read The Lady Tasting Tea: How Statistics Revolutionized Science in the Twentieth Century, by David Salsburg. This book provides a historical introduction to statistical and environetics principles that will be the focus of the first half of the course. Students are expected to read the entire book. The purpose of this reading is to introduce students to the field of statistics and to prepare them for the concepts and language of uncertainty, which permeates statistical thought.
Problem Sets
Problem sets are due as noted in the lecture schedule. There will be a 20% reduction in the grade for each day that a problem set is late.
Quizzes
There will be two quizzes during the term. The second quiz will only cover material presented after the first quiz. Quizzes will be given inclass during the regular lecture period as noted in the schedule. Quiz #1 is open book. The format of Quiz #2 will be determined by instructors. There is no final examination.
Team Project
Students will be grouped into teams of 34 students to work jointly on a project to investigate an environmental agent for which there is reason for concern about possible adverse health effects for human populations. The investigation will center on concepts developed during the term, with emphasis on relating environmental exposures and toxicological mechanisms to quantitative risk assessment of potential health effects.
Calendar
Course schedule.
Lec # 
Topics 
INSTRUCTORS 
KEY DATES 
1 
Introductory Lecture 
Prof. James Sherley
Prof. Steven Tannenbaum
Dr. Laura Green 

2 
Watch film A Civil Action 
Prof. James Sherley
Prof. Steven Tannenbaum
Dr. Laura Green 

3 
From the Real World to Hollywood and Back Again 
Dr. Laura Green 

4 
Epidemiology: Persons, Places, and Time 
Prof. James Sherley 

5 
Epidemiology: Test Development and Relative Risk 
Prof. James Sherley 

6 
Biostatistics: Concepts in Variance 
Prof. James Sherley 
Problem set 1 Epidemiology out 
7 
Biostatistics: Distribution and the Mean
Confidence Intervals 
Prof. James Sherley 
Problem set 2 Biostatistics 1 out
Problem set 1 Epidemiology due 
8 
Biostatistics: Detecting Differences and Correlations 
Prof. James Sherley 

9 
Biostatistics: Poisson Analyses and Power 
Prof. James Sherley 
Problem set 3 Biostatistics 2 out
Problem set 2 Biostatistics 1 due
Team project topic deadline 
10 
Environetics: Cause and Effect 
Prof. James Sherley 

11 
Environetics: Study Design  Retrospective versus Prospective 
Prof. James Sherley 
Problem set 3 Biostatistics 2 due
Team project approvals completed 
12 
Environetics: Putting it all together  Evaluating Studies 
Prof. James Sherley 
Lady Tasting Tea 10page review due 
13 
Quiz #1: EpidemiologyBiostatistics 
Prof. James Sherley 

14 
Evaluating Environmental Causes of Mesothelioma 
Prof. James Sherley 

15 
Quantitative Risk Assessment 1 
Dr. Laura Green 

16 
Quantitative Risk Assessment 2 
Dr. Laura Green 

17 
Toxicology 1 
Prof. Steven Tannenbaum 

18 
Toxicology 2 
Prof. Steven Tannenbaum 
Problem set 4 Toxicology 1 out 
19 
Toxicology 3 
Prof. Steven Tannenbaum 

20 
Toxicology 4 
Prof. Steven Tannenbaum 
Problem set 5 Toxicology 2 out
Problem set 4 Toxicology 1 due 
21 
Toxicology 5 
Prof. Steven Tannenbaum 

22 
Quantitative Risk Assessment 3 
Dr. Laura Green 
Problem set 5 Toxicology 2 due 
23 
Quantitative Risk Assessment 4 
Dr. Laura Green 

24 
Quiz #2: QRAToxicology 
Dr. Laura Green
Prof. Steven Tannenbaum 

25 
Classroom Presentations of Team Projects 

20page team papers due in class 
26 
Classroom Presentations of Team Projects (cont.) 





Further Reading:

Readings
The readings in the table below are from the following course textbooks:
Gordis, L. Epidemiology. 3rd ed. Philadelphia, PA: W.B. Saunders, 2004. ISBN: 9780721603261.
Schork, M. A., and R. D. Remington. Statistics with Applications to the Biological and Health Sciences. 3rd ed. Upper Saddle River, NJ: PrenticeHall, 2000. ISBN: 9780130223272.
Course Readings
LEC # 
TOPICS 
INSTRUCTORS 
READINGS 
1 
Introductory Lecture 
Prof. James Sherley
Prof. Steven Tannenbaum
Dr. Laura Green 

2 
Watch film A Civil Action 
Prof. James Sherley
Prof. Steven Tannenbaum
Dr. Laura Green 

3 
From the Real World to Hollywood and Back Again 
Dr. Laura Green 

4 
Epidemiology: Persons, Places, and Time 
Prof. James Sherley 
Gordis. Chapters 1 and 2. 
5 
Epidemiology: Test Development and Relative Risk 
Prof. James Sherley 
Gordis. Chapters 35, 11, and 12.
Schork and Remington. Sections 81, 85, 862, and 88. 
6 
Biostatistics: Concepts in Variance 
Prof. James Sherley 
Schork and Remington. Chapters 1 and 2, sections 41, 42, 44 to 47. 
7 
Biostatistics: Distribution and the Mean
Confidence Intervals 
Prof. James Sherley 
Schork and Remington. Sections 51, 52, 54, 561, 562, 568, 60, 61, 62, 77, and 771. 
8 
Biostatistics: Detecting Differences and Correlations 
Prof. James Sherley 
Schork and Remington. Sections 63, 72, 73, 74, 101 to 104, and 106. 
9 
Biostatistics: Poisson Analyses and Power 
Prof. James Sherley 
Schork and Remington. Sections 30, 31, 52, 55, 67, 70, 71, 91, 911, 9123, and 143. 
10 
Environetics: Cause and Effect 
Prof. James Sherley 
Gordis. Chapters 1416. 
11 
Environetics: Study Design  Retrospective versus Prospective 
Prof. James Sherley 
Gordis. Chapters 710, and 13.
Hecht, S. S., et al. "Metabolites of a Tobaccospecific Lung Carcinogen in the Urine of Elementary Schoolaged Children." Cancer Epidemiology, Biomarkers & Prevention 10 (November 2001): 1109–1116.
Hunt, P. A., et al. "Bisphenol A Exposure Causes Meiotic Aneuploidy in the Female Mouse." Current Biology 13 (April 1, 2003): 546–553.
Proctor, R. N. "Tobacco and the global lung cancer epidemic." Nature Reviews Cancer 1 (October 2001): 8286. 
12 
Environetics: Putting it all together  Evaluating Studies 
Prof. James Sherley 
Selected readings of original literature. 
13 
Quiz #1: EpidemiologyBiostatistics 
Prof. James Sherley 

14 
Evaluating Environmental Causes of Mesothelioma 
Prof. James Sherley 

15 
Quantitative Risk Assessment 1 
Dr. Laura Green 

16 
Quantitative Risk Assessment 2 
Dr. Laura Green 

17 
Toxicology 1 
Prof. Steven Tannenbaum 
Wogan, G. N., et al. "Environmental and chemical carcinogenesis." Seminars in Cancer Biology 14 (2004): 473–486. 
18 
Toxicology 2 
Prof. Steven Tannenbaum 

19 
Toxicology 3 
Prof. Steven Tannenbaum 

20 
Toxicology 4 
Prof. Steven Tannenbaum 

21 
Toxicology 5 
Prof. Steven Tannenbaum 

22 
Quantitative Risk Assessment 3 
Dr. Laura Green 

23 
Quantitative Risk Assessment 4 
Dr. Laura Green 

24 
Quiz #2: QRAToxicology 
Dr. Laura Green
Prof. Steven Tannenbaum 

25 
Classroom Presentations of Team Projects 


26 
Classroom Presentations of Team Projects (cont.) 





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