Health Sciences > Microbiology > Cellular and Molecular Immunology

Cellular and Molecular Immunology posted by duggu on 11/23/2007

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Abstract/Syllabus

Courseware/Lectures

Test/Tutorials

Course Highlights

This course features downloadable lecture notes and exams.

Course Description

This course covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation, including molecular structure and assembly of MHC molecules, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immunologically mediated diseases. The course is structured as a series of lectures and tutorials in which clinical cases are discussed with faculty tutors.

Syllabus

Overview

Although this is an introductory immunology course, we will deal with the subject in quite some detail which will build as the course progresses. Immunological aspects of disease will be covered in the classroom as well as in case-based tutorial sessions, and in evening clinical discussions at selected teaching hospitals.

Tutorials

Apart from the lectures there will be seven tutorial sessions at which attendance is required. At these sessions immunologically relevant clinical cases will be discussed. The goal will be to use these sessions to review and revise basic immunological issues as well as to get a feel for disease processes. Please see the section in the camel regarding the clinical curriculum.

There will be five tutorial groups each of which will be led by a faculty tutor. Students and individual tutors will remain in the same tutorial group for the duration of the course.

Texts

A "basic" textbook and a clinical textbook are recommended. The recommended books are:

Abbas, Abul K., and Andrew Lichtman. Cellular and Molecular Immunology. 6th ed. Philadelphia, PA: Saunders, 2005. ISBN: 1416023895.

Rosen, Fred, and Raif Geha. Case Studies in Immunology: A Clinical Companion. 4th ed. New York, NY: Garland Pub., 2004. ISBN: 0815341024. (Paperback)

Reading of textbook chapters before the class is strongly recommended. For many of the lectures the contents of the slides are summarized in the course camel. The current edition of the following book may also be used:

Janeway, Charles A., et al. Immunobiology: The Immune System in Health and Disease. New York, NY: Garland Science, 2005. ISBN: 0443073104.

Exams and Grades

Two short quizzes are planned early in the course to facilitate acquisition of the "language of immunology." There will be a Mid-term as well as a Final examination (short answers and brief essays). Grades will be based primarily on performance in the quizzes and examinations.

Calendar

Course Schedule.
SES #	TOPICS	KEY DATES
1	Overview - Dr. Shiv Pillai
2	Cells of the Immune System - Dr. Shiv Pillai
3	Lymphocyte Homing - Dr. Ulrich von Andrian
4	Case Presentations at MGH
5	Antibodies and Antigens - Dr. Shiv Pillai Analyzing a Clinical Case - Dr. Bobby Cherayil
6	Antigen Receptors and the Generation of Diversity - Dr. Shiv Pillai	Quiz I
7	Case Presentations at MGH
8	B Lymphocyte Development and Activation - Dr. Shiv Pillai
9	Tutorial Session I Antibody Dependent Protection - Dr. Shiv Pillai
10	Antigen Presentation - Dr. Hidde Ploegh
11	Tutorial Session II T Lymphocyte Development - Dr. Shiv Pillai	Quiz II
12	Tutorial Session III Signal Transduction in Lymphocytes I - Dr. Shiv Pillai
13	Cell Mediated Immunity - Dr. Andrew Lichtman
14	Tutorial Session IV Signal Transduction in Lymphocytes II - Dr. Shiv Pillai
15	Paper Discussion 1
	Midterm Exam
16	Dendritic Cells - Dr. Shannon Turley Frontiers: Costimulation - Dr. Arlene Sharpe
17	Paper Discussion 2
18	Memory and Death - Dr. Shiv Pillai Immunology of TB - Dr. Samuel M. Behar
19	Tutorial Session V Immune Mediated Injury - Dr. Richard Mitchell
20	Asthma and Allergy - Dr. Dale T. Umetsu Frontiers: DC and Innate Immunity - Dr. Nir Harcohen
21	Multiple Sclerosis - Dr. David Hafler Frontiers: Autoimmune TCRs - Dr. Kai Wucherpfennig
22	Paper Discussion 3
23	Leukemias and Lymphomas - Dr. Jon C. Aster CD1 and Lipid Antigens - Dr. Richard S. Blumberg
24	Tutorial Session VI Transplantation Immunology - Dr. Hugh Auchincloss
25	Immunology of HIV/AIDS - Dr. Bruce Walker Frontiers: Genetic Instability and Cancer - Dr. Frederick W. Alt
26	Regulatory T Cells - Dr. Diane Mathis Bone Marrow Transplant - Dr. Megan Sykes
27	Tutorial Session VII Tumor Immunology - Dr. Andrew Lichtman
28	Paper Discussion 4
29	Regulating Humoral Autoimmunity - Dr. Shiv Pillai Inflammatory Bowel Disease - Dr. Ramnik Xavier
30	Immunodeficiency Disorders - Dr. Francisco Bonilla
31	RA and Lupus - Dr. Paul Anderson
32	Genetic Susceptibility to Disease - Dr. Shiv Pillai
	Final Exam

Readings

Required Readings

Abbas, Abul K., and Andrew Lichtman. Cellular and Molecular Immunology. 6th ed. Philadelphia, PA: Saunders, 2005. ISBN: 1416023895.

Rosen, Fred, and Raif Geha. Case Studies in Immunology: A Clinical Companion. 4th ed. New York, NY: Garland Pub., 2004. ISBN: 0815341024. (Paperback)

Janeway, Charles A., et al. Immunobiology: The Immune System in Health and Disease. New York, NY: Garland Science, 2005. ISBN: 0443073104.

DeGowin, Richard L., and Donald D. Brown. DeGowin's Diagnostic Examination. New York, NY: McGraw-Hill, Health Professions Division, 2000. ISBN: 0070164436.

Kasper, Dennis L., Eugene Braunwald, Anthony Fauci, Stephen Hauser, Dan Longo, and J. Larry Jameson. Harrison's Principles of Internal Medicine. 16th ed. New York, NY: McGraw-Hill, Medical Pub. Division, 2005. ISBN: 0071402357.

Discussion Papers

Readings files.
SES #	TOPICS	READINGS
15	Paper Discussion 1	Forster, R., A. Schubel, D. Breitfeld, E. Kremmer, I. Renner-Muller, E. Wolf, and M. Lipp. "CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs." Cell 99, no. 1 (October 1, 1999): 23-33.
17	Paper Discussion 2	Fisher, G. H., F. J. Rosenberg, S. E. Straus, J. K. Dale, L. A. Middleton, A. Y. Lin, W. Strober, M. J. Lenardo, and J. M. Puck. "Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome." Cell 81, no. 6 (June 16, 1995): 935-46.
22	Paper Discussion 3	Murali-Krishna, K., L. L. Lau, S. Sambhara, F. Lemonnier, J. Altman, and R. Ahmed. "Persistence of memory CD8 T cells in MHC class I-deficient mice." Science 286, no. 5443 (November 12, 1999): 1377-81.
28	Paper Discussion 4	Fontenot, J. D., M. A. Gavin, and A. Y. Rudensky. "Foxp3 programs the development and function of CD4+CD25+ regulatory T cells." Nat Immunol 4, no. 4 (April 2003): 330-6. (Epub March 3, 2003)

Optional Readings

McMichael, A. J., and S. L. Rowland-Jones. "HIV: Bad news for stop-start therapy?" Nature 420, no. 6914 (November 28, 2002): 371, and 373.

Chaudhuri, J., M. Tian, C. Khuong, K. Chua, E. Pinaud, F. W. Alt. "Transcription-targeted DNA deamination by the AID antibody diversification enzyme." Nature 422, no. 6933 (April 17, 2003): 726-30. (Epub April 9, 2003)

Rosen, F. S., M. D. Cooper, and R. J. Wedgwood. "The primary immunodeficiencies." N Engl J Med 333, no. 7 (August 17, 1995): 431-40.