Required Texts
Salsburg, D. The Lady Tasting Tea: How Statistics Revolutionized Science in the Twentieth Century. New York, NY: W. H. Freeman and Company, 2001. ISBN: 0716741067.
Gordis, L. Epidemiology. 3rd ed. Philadelphia, PA: Elsevier, 2004. ISBN: 0721603262.
Schork, M. A., and R. D. Remington. Statistics with Applications to the Biological and Health Sciences. 3rd ed. Upper Saddle River, NJ: PrenticeHall, 2000. ISBN: 0130223271.
Grading Policy
Percentage contributions to the final grade are as follows:
Grading Table
Activities 
Percentages 
Quizzes (Two, 25% each)

50%

Homework Assignments (10page Book Critique, 10%; 5 Problem Sets, 15%)

25%

Team Project (Team Project Paper, 15%; Team Project Presentation, 10%)

25%

Recitations
There will be optional weekly recitation sessions offered throughout the term. However, students are strongly encouraged to attend. In addition to answering questions relating to the lecture material, homework assignments, and projects, the TA will provide background help with concepts in several areas, including epidemiology and biostatistics for the first half and elements of chemistry and biochemistry and risk analyses for the second.
Reading Assignment for "The Lady Tasting Tea"
During the first half of the term, students are required to read The Lady Tasting Tea: How Statistics Revolutionized Science in the Twentieth Century, by David Salsburg. This book provides a historical introduction to statistical and environetics principles that will be the focus of the first half of the course. Students are expected to read the entire book. The purpose of this reading is to introduce students to the field of statistics and to prepare them for the concepts and language of uncertainty, which permeates statistical thought.
Problem Sets
Problem sets are due as noted in the lecture schedule. There will be a 20% reduction in the grade for each day that a problem set is late.
Quizzes
There will be two quizzes during the term. The second quiz will only cover material presented after the first quiz. Quizzes will be given inclass during the regular lecture period as noted in the schedule. Quiz #1 is open book. The format of Quiz #2 will be determined by instructors. There is no final examination.
Team Project
Students will be grouped into teams of 34 students to work jointly on a project to investigate an environmental agent for which there is reason for concern about possible adverse health effects for human populations. The investigation will center on concepts developed during the term, with emphasis on relating environmental exposures and toxicological mechanisms to quantitative risk assessment of potential health effects.
Calendar
Course schedule.
Lec # 
Topics 
INSTRUCTORS 
KEY DATES 
1

Introductory Lecture

Prof. James Sherley
Prof. Steven Tannenbaum
Dr. Laura Green


2

Watch film A Civil Action

Prof. James Sherley
Prof. Steven Tannenbaum
Dr. Laura Green


3

From the Real World to Hollywood and Back Again

Dr. Laura Green


4

Epidemiology: Persons, Places, and Time

Prof. James Sherley


5

Epidemiology: Test Development and Relative Risk

Prof. James Sherley


6

Biostatistics: Concepts in Variance

Prof. James Sherley

Problem set 1 Epidemiology out

7

Biostatistics: Distribution and the Mean
Confidence Intervals

Prof. James Sherley

Problem set 2 Biostatistics 1 out
Problem set 1 Epidemiology due

8

Biostatistics: Detecting Differences and Correlations

Prof. James Sherley


9

Biostatistics: Poisson Analyses and Power

Prof. James Sherley

Problem set 3 Biostatistics 2 out
Problem set 2 Biostatistics 1 due
Team project topic deadline

10

Environetics: Cause and Effect

Prof. James Sherley


11

Environetics: Study Design  Retrospective versus Prospective

Prof. James Sherley

Problem set 3 Biostatistics 2 due
Team project approvals completed

12

Environetics: Putting it all together  Evaluating Studies

Prof. James Sherley

Lady Tasting Tea
10page review due 
13

Quiz #1: EpidemiologyBiostatistics

Prof. James Sherley


14

Evaluating Environmental Causes of Mesothelioma

Prof. James Sherley


15

Quantitative Risk Assessment 1

Dr. Laura Green


16

Quantitative Risk Assessment 2

Dr. Laura Green


17

Toxicology 1

Prof. Steven Tannenbaum


18

Toxicology 2

Prof. Steven Tannenbaum

Problem set 4 Toxicology 1 out

19

Toxicology 3

Prof. Steven Tannenbaum


20

Toxicology 4

Prof. Steven Tannenbaum

Problem set 5 Toxicology 2 out
Problem set 4 Toxicology 1 due

21

Toxicology 5

Prof. Steven Tannenbaum


22

Quantitative Risk Assessment 3

Dr. Laura Green

Problem set 5 Toxicology 2 due

23

Quantitative Risk Assessment 4

Dr. Laura Green


24

Quiz #2: QRAToxicology

Dr. Laura Green
Prof. Steven Tannenbaum


25

Classroom Presentations of Team Projects


20page team papers due in class

26

Classroom Presentations of Team Projects (cont.)

