Overview
This lecture based course covers the growth, development and structure of normal bone and joints, the biomechanics of bone connective tissues, and their response to stress, calcium and phosphate homeostasis. Additional topics include regulation by parathyroid hormone and vitamin D, the pathogenesis of metabolic bone diseases and diseases of connective tissues, joints and muscle with consideration of possible mechanisms and underlying metabolic derangements.
Assignments
There is one problem set and a final exam for this course.
Grading
| Activities |
Percentages |
| Problem Set |
10% |
| Final Exam |
90% |
Calendar
| SES # |
TOPICS |
KEY DATES |
| 1 |
Bone Growth and Development (1 hr.) - Dr. Schiller
Bone Growth; Fracture Healing (1 hr.) - Dr. Schiller |
|
| 2 |
Infections of Bone/Metabolic Bone Disease (1 hr.) - Dr. Schiller
Histology of Bone; Microscopic Lab (1 hr.) - Dr. Schiller |
|
| 3 |
Disorders of Growth Plate (1 hr.) - Dr. Olsen
Heritable Disorders of Connective Tissues (1 hr.) - Dr. Krane |
|
| 4 |
Basic Skeletal Biomechanics (1 hr.) - Dr. Snyder
Biomechanics of Fracture Healing (1 hr.) - Dr. Snyder |
|
| 5 |
Cartilage Biology and Biomechanics (1 hr.) - Dr. Kim
Biomechanics in Pathogenesis of Osteoarthritis (1 hr.) - Dr. Kim |
|
| 6 |
Rheumatic Diseases (I) (1 hr.) - Dr. Robinson
Rheumatic Diseases (II), SLE, Scleroderma (1 hr.) - Dr. Robinson |
|
| 7 |
Pathogenesis of Rheumatoid Arthritis (1 hr.) - Dr. Anderson
Rheumatic Diseases (III), Vasculitis, Gout (1 hr.) - Dr. Robinson |
|
| 8 |
Biomechanics Review Session (1 hr.) |
|
| 9 |
Muscular Dystrophies/ Inflammatory Myopathies (1 hr.) - Dr. Brown
Mitochondrial Myopathies (1 hr.) - Dr. Johns
Mineral Ion Homeostasis (2 hrs.) - Dr. Potts |
|
| 10 |
Osteoporosis; Osteomalacia (1 hr.) - Dr. DeMay
Cartilage; Structure Osteoarthritis (1 hr.) - Dr. Mankin
Demonstration: Joint Dissection (30 min.) - Dr. Mankin |
Problem set due |
| |
Final Examination (2.5 hrs.) |
|