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 Cell Biology: Structure and Functions of the Nucle  posted by  duggu   on 12/10/2007  Add Courseware to favorites Add To Favorites  
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Abstract/Syllabus:

Sharp, Phillip, and Richard Young, 7.60 Cell Biology: Structure and Functions of the Nucleus, Spring 2006. (Massachusetts Institute of Technology: MIT OpenCourseWare), http://ocw.mit.edu (Accessed 08 Jul, 2010). License: Creative Commons BY-NC-SA

Graphic illustration of a cell nucleus.

Graphic illustration of a cell nucleus. (Image courtesy of the U.S. National Library of Medicine.)

Course Highlights

This course features a bibliography of readings.

Course Description

This course covers the fundamentals of nuclear cell biology as well as the methodological and experimental approaches upon which they are based. Topics include Eukaryotic genome structure, function, and expression, processing of RNA, and regulation of the cell cycle. The techniques and logic used to address important problems in nuclear cell biology is emphasized. Lectures cover broad topic areas in nuclear cell biology and class discussions focus on representative papers recently published in the field.

Syllabus

 
 

Course Description

The goal of this course is to teach both the fundamentals of nuclear cell biology as well as the methodological and experimental approaches upon which they are based. Class meetings at the start of the week will generally be lectures describing the background and fundamental findings in a particular area of nuclear cell biology. The second session class meetings of the week will generally be a group discussion of one assigned paper in the same area. These seminal papers are used to understand both the important elements of the field as well as to provide concrete examples of the experimental approaches and logic used to establish these findings. Two students will be assigned to present the paper for each discussion based class and faculty and students will participate in the discussion. All students will be expected to have read the paper under consideration and be prepared for a lively discussion.

Enrollment is open to all biology graduate students and undergraduates by permission.

Evaluation

Students will be evaluated by two criteria. Participation in class discussions will constitute 50% of the grade. The remaining 50% of the evaluation will be based on a written proposal due at the end of the semester.


ACTIVITIES PERCENTAGES
Class Discussions 50%
Written Proposal 50%

Calendar

 
 

PAS = Prof. Phillip Sharp
RAY = Prof. Richard A. Young


SES # TOPICS LECTURERS
1 Introduction: Nucleus RAY
2 Lecture: Genome RAY
3 Discussion: Genome  
4 Lecture: Cell Cycle Control RAY
5 Discussion: Cell Cycle Control  
6 Lecture: Transcription Apparatus and Regulators RAY
7 Discussion: Transcription Apparatus and Regulators  
8 Lecture: Chromatin and Gene Expression I PAS
9 Discussion: Chromatin and Gene Expression I  
10 Lecture: Chromatin and Gene Expression II RAY
11 Discussion: Chromatin and Gene Expression II  
12 Lecture: Genome Replication/Repair Guest Lecturer: Prof. Angelika Amon
13 Discussion: Genome Replication/Repair  
14 Lecture: Nuclear Structure, Import/Export PAS
15 Discussion: Nuclear Structure, Import/Export  
16 Lecture: DNA Modification/Epigenetics Guest Lecturer: Prof. Rudy Jaenisch
17 Discussion: DNA Modification/Epigenetics  
18 Lecture: Alternative Splicing/Polyadenylation PAS
19 Discussion: Alternative Splicing/Polyadenylation  
20 Lecture: Signal Transduction RAY
21 Discussion: Signal Transduction  
22 Lecture: RNA Interference I - Silencing and microRNAs PAS
23 Discussion: RNA Interference I - Silencing and microRNAs  
24 Lecture: RNA Interference II - Transcription PAS
25 Discussion: RNA Interference II - Transcription  
26 Course Review: Group Discussion  
 

 




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