Share Course Ware
Health Sciences > Biochemistry > Magnetic Resonance Analytic, Biochemical, and Imag
 Magnetic Resonance Analytic, Biochemical, and Imag  posted by  duggu   on 11/26/2007  Add Courseware to favorites Add To Favorites  
Further Reading
More Options

Rosen, Bruce, and Lawrence Wald, HST.584J Magnetic Resonance Analytic, Biochemical, and Imaging Techniques, Spring 2006. (Massachusetts Institute of Technology: MIT OpenCourseWare), (Accessed 09 Jul, 2010). License: Creative Commons BY-NC-SA

An MRI image of a human brain.

An MRI image of a human brain. (Image courtesy of the A. A. Martinos Center.)

Course Highlights

This course features extensive course notes and papers in the readings section, as well as complete assignments with solutions.

Course Description

This course is an introduction to basic NMR theory. Examples of biochemical data obtained using NMR are summarized along with other related experiments. Students participate in detailed study of NMR imaging techniques, including discussions of basic cross-sectional image reconstruction, image contrast, flow and real-time imaging, and hardware design considerations. Exposure to laboratory NMR spectroscopic and imaging equipment is included.



This spring term course is designed for graduate (or advanced undergraduate) students and research scientists with an interest in how nuclear magnetic resonance (NMR) techniques can be used to provide information of value to biological scientists and physicians. The course will introduce basic NMR theory, including spectroscopic and relaxation phenomena. Examples of biochemical data obtained using NMR will be summarized, along with other, related experiments. The course will then focus on imaging with NMR, and include discussions of basic cross sectional image reconstruction, image contrast, flow and real time imaging, and microscopy.

Course Requirements

Midterm Quiz 30%
Weekly Problem Sets 60%
Class Presentation 10%


Lecture notes, journal articles and book chapters will be handed out in class to supplement the class lectures.


1 Introductory Remarks, Course Requirements

Introduction to NMR

Classical Model of the NMR Phenomenon

The Bloch Equations
2 Relaxation Mechanisms and Measurement

Proton Relaxation Enhancement

Effects of Magnetic Susceptibility

Introduction to Pulse Sequences
3 Review of Rotating Frame

Spin Echos

Ernst Angle

Off-resonance Effects
Assignment 1 due
4 Image Contrast (T1, T2 Weighting)

Basic NMR Spectroscopy

Chemical Shifts, J-coupling

Basic Pulse Sequences in Uncoupled and Coupled Systems
Assignment 2 due
5 Image Encoding

Fourier Transforms and Properties

Image Resolution - Point Spread Function
6 Review of k-space Formalism

Review of Resolution and Sampling - Nyquist Rate

MR Image Reconstruction

Gradient and RF Waveforms
7 Errors in Imaging (Ghosting) Assignment 3 due

Midterm Quiz
8 MRI Hardware Overview  
9 Additional Pulse Sequences

Chemical Shift Imaging and Flow Imaging Techniques

2-D and 3-D CSI

Time of Flight and Phase Contrast Flow Imaging
10 Guest Lecturer - Van Wedeen, PhD

Diffusion-weighted MR Techniques
11 Parallel Imaging

MR Encoding Matrix Formalism

Multiple Coil Formalism

Assignment 4 due
12 Guest Lecturer - Alan Jasanoff, PhD

Molecular Imaging Techniques

Guest Lecturer - Elfar Adalsteinsson, PhD

Advanced Image Reconstruction
13 Guest Lecturer - Robert Savoy, PhD

Introduction to fMRI and Experiment Design
Assignment 5 due
14 Class Presentations Final Project due   Tell A Friend