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Abstract/Syllabus:
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Principles of Human Nutrition
Fall 2004

A mother feeds her infant at a nutrition center in Nouakchott, Mauritania. ©1991 Lauren Goodsmith, Courtesy of Photoshare
Instructor
Benjamin Caballero
Offered By
International Health
Description
Principles of Human Nutrition (222.641) provides an integrated overview of the physiological requirements and functions of protein, energy, and the major vitamins and minerals that are determinants of health and diseases in human populations. Topics include the following:
- Dietary sources, intake levels, physiological role, and requirement of major nutrients.
- The biological determinants of nutrient requirements and the assessment of nutrient status in individuals and populations.
- The role of nutrition in growth and health through the life cycle.
- The rationale for the development of dietary guidelines and of nutrition policies in different countries.
- The role of diet in the development of chronic diseases, such as cardiovascular disease, cancer, diabetes, etc.
Syllabus
Course Description
Principles of Human Nutrition (222.641) provides an integrated overview of the physiological requirements and functions of protein, energy, and the major vitamins and minerals that are determinants of health and diseases in human populations. Topics include the following:
- Dietary sources, intake levels, physiological role, and requirement of major nutrients.
- The biological determinants of nutrient requirements and the assessment of nutrient status in individuals and populations.
- The role of nutrition in growth and health through the life cycle.
- The rationale for the development of dietary guidelines and of nutrition policies in different countries.
- The role of diet in the development of chronic diseases, such as cardiovascular disease, cancer, diabetes, etc.
Course Objectives
Upon completion of this course, you will be able to do the following:
- Provide an overview of the major macro and micronutrients relevant to human health.
- Discuss the scientific rationale for defining nutritional requirements in healthy individuals and populations, with reference to specific conditions such as pregnancy, lactation, and older age.
- Present current evidence for the role of key nutrients in the prevention of chronic diseases.
- Discuss major nutrition-related diseases in a global context.
Readings
Required Reading:
- J. Mann and S. Truswell (2nd edition, 2002). Essentials of Human Nutrition. Oxford University Press.
Recommended Reading:
- Encyclopedia of Human Nutrition (1998). London: Academic Press.
- Shils, Olson, Shike, and Ross (Eds.), (1999). Modern Nutrition in Health and Disease, 9th edition. Williams and Wilkins.
- Linder, Ed. (1991). Nutritional Biochemistry and Metabolism, 2nd edition. Elsevier.
Schedule
Introduction |
Lecture 1 |
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Calculation of Anthropometric Measurements |
Assignment 1 |
Energy Homeostasis in Humans |
Lecture 2 |
Proteins and Amino Acids |
Lecture 3 |
Lipids |
Lecture 4 |
Management of a Public Health Menace: Obesity |
Lecture 5 |
Protein-Energy Malnutrition |
Lecture 6 |
Energy Metabolism and Macronutrients |
Quiz 1 |
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Content 2 |
Assignment 2 |
Vitamin A, Vitamin E, and Carotenoids |
Lecture 7 |
Antioxidant Nutrients |
Lecture 8 |
Iron and Other Hematopoietic Nutrients |
Lecture 9 |
Calcium, Phosphorus, and Vitamin D |
Lecture 10 |
Iodine |
Lecture 11 |
Dietary Supplements and Fortified Foods |
Lecture 12 |
Micronutrients |
Quiz 2 |
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Maternal Nutrition |
Lecture 13 |
Fetal Nutrition |
Lecture 14 |
Growth and Nutrition during Infancy |
Lecture 15 |
Extra Credit Quiz |
Quiz 3 |
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Further Reading:
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Readings
Textbooks
Required Reading:
- J. Mann and S. Truswell (2nd edition, 2002). Essentials of Human Nutrition. Oxford University Press.
Recommended Reading:
- Encyclopedia of Human Nutrition (1998). London: Academic Press.
- Shils, Olson, Shike, and Ross (Eds.), (1999). Modern Nutrition in Health and Disease, 9th edition. Williams and Wilkins.
- Linder, Ed. (1991). Nutritional Biochemistry and Metabolism, 2nd edition. Elsevier.
Introduction |
Food Science, Nutrition and Health, Fox & Cameron - Chapter 1: Food and Its Functions
Recommended Dietary Allowances, NAS - Chapter 2: Definition and Applications
Nutrition, ILSI - Chapter 64: Present Knowledge
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Energy Homeostasis in Humans |
WHO Technical Report No. 724 - Chapters 2 and 4
RDA, 10th Edition - Chapter 3
Jequier E, Acheson K, Schutz Y: Assessment of energy expenditure and fuel utilization in man. Ann Rev Nutr 1987; 7: 187-208.
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Proteins and Amino Acids |
Food Science, Nutrition and Health, Fox & Cameron - Chapter 9
FAO/WHO Technical Report #724 - Chapters 5 and 6
RDA 10th Edition - Chapter 6
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Lipids |
Food Science, Nutrition and Health, Fox & Cameron - Chapter 5
Lipids: Recommended Dietary Allowances (10th edition) - Chapter 5
Garrow JS: Is there a body protein reserve? Proc Nutr Soc 1982; 41: 270-272
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Management of a Public Health Menace: Obesity |
Pi-Sunyer FX. Obesity, in: Modern Nutrition in Health and Disease, pp 984-1006, Lea & Febiger, 1994.
Cheskin, LJ Obesity, in Current Therapy in Gastroenterology and Liver Disease, pp 181-188, Mosby, 1994.
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Protein-Energy Malnutrition |
Viteri FE: Primary protein-energy malnutrition: clinical, biochemical, and metabolic changes. In: Textbook of Pediatric Nutrition. RM Suskind, editor. Raven Press, NY, 1981, pp 189-215.
Picou DM: Evaluation and treatment of the malnourished child. In: Textbook of Pediatric Nutrition. RM Suskind, editor. Raven Press, NY, 1981, pp 217-228.
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Vitamin A, Vitamin E, and Carotenoids |
Ross AC, Ternus ME. Vitamin A as a hormone: Recent advances in understanding the actions of retinol, retinoic acid, and beta carotene. J Am Diet Assoc 1993; 93: 1285-1290.
Rock CL, Jacob RA, Bowen PE . Update on the biological characteristics of the antioxidant micronutrients: Vitamin C, vitamin E, and the caretenoids. J Am Diet Assoc 1996; 96: 693-702.
Olson JA. 1992 Atwater Lecture. The irresistible fascination of caretenoids and vitamin A. Am J Clin Nutr 1993; 57: 833-839. |
Antioxidant Nutrients |
Gaziano M. Antioxidants in cardiovascular disease: randomized trials. Nutrition Reviews 54:175; 1996.
Fox & Cameron: Chapter 3: Food, health and disease.
Appel LJ et al. A clinical trial of the effects of dietary patterns on blood pressure. New Engl J Med 336:1117; 1997.
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Iron and Other Hematopoietic Nutrients |
Recommended Dietary Allowances, 10th ed., National Academy Press, 1989: Chapter on iron (pp. 195-205) and folate and B12 (pp. 150-165).
Modern Nutrition in Health and Disease, 8th edition: Ch 9., Iron in medicine and nutrition (pp. 185-213).
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Calcium, Phosphorus, and Vitamin D |
Recommended Dietary Allowances, 10th ed., National Academy Press, 1989: Chapter on iron (pp. 195-205) and folate and B12 (pp. 150-165).
Modern Nutrition in Health and Disease, 8th edition: Ch 9., Iron in medicine and nutrition (pp. 185-213). |
Iodine |
No readings assigned |
Dietary Supplements and Fortified Foods |
No readings assigned |
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Maternal Nutrition |
No readings assigned |
Fetal Nutrition |
No readings assigned |
Growth and Nutrition during Infancy |
No readings assigned |
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